It is noteworthy that when the drugs were used in combination the effects of theophylline and salbutamol were additive in inhibiting tnfalpha. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be. This document does not contain all possible drug interactions. Pharmacist intervention and knowledge in the drug disease interaction, considering the pharmacokinetics data, would be. Adverse reactions and interactions with theophylline springerlink. Interactions between theophylline and salbutamol on. Interaction between phenytoin and theophylline in healthy. Drug interactions are reported among people who take levofloxacin and theophylline together. Drug interactions may change how your medications work or increase your risk for serious side effects. Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see commonlyused drugs that interact with theophylline. Elimination of theophylline from the body occurs mainly approximately 90% by biotransformation, followed by excretion of the metabolites. Both smoking and excessive caffeine consumption can alter the blood levels of theophylline, which may affect the dosing. In vitro studies indicate that montelukast does not inhibit cyp450 enzymes.
However, it may also be brought about by interference of its metabolism secondary to the concurrent administration of other drugs. Levofloxacin and theophylline drug interactions a study of. In this paper, we introduced an automatic computational method for the systematic. Theophylline is now usually used as an addon therapy in asthma patients not well controlled on inhaled. Interactions between drugs in vitro eg, precipitation when mixed in solutions for intravenous administration are usually classified as drug incompatibilities, not drug interactions.
Identifying drugdrug interaction ddi is an important topic for the development of safe pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases such as cancer and hiv. Taking theophylline with propranolol can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. This may reduce the effectiveness of the medication. Danger of interaction between ciprofloxacin and theophylline br med j clin res ed 1988.
Effect of drug interactions on outcomes of patients receiving. A blood sample should usually be taken 46 hours after an oral dose of a modifiedrelease preparation sampling times may varyconsult local guidelines. Drug interactions are particularly important and are listed in table 2. Theophylline appears to have an effect that is different from those of corticosteroids, and it may therefore be a useful drug to combine with lowdose inhaled steroids. Pharmacokinetic drug interactions with theophylline. Data were collected from medical records during a oneyear period in two community teaching hospitals in maryland. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage, preferably. Theophylline interactions bnf content published by nice.
T here is a strong relationship between the number of medications taken and the likelihood of a potentially serious drugdrug interaction. Johns wort without first talking with your healthcare provider. Drug interactions are reported among people who take theophylline and alcohol together. A drug interaction between zafirlukast and theophylline.
Theophylline oral interactions with other medication. Johns wort can decrease the level of theophylline in your blood, perhaps making it less effective. Clinical studies indicate that the drug does not interact with theophylline malmstrom, am j ther. There have been about 150,000 publications on ddis in pubmed, which is a great resource for ddi studies. It is important to recognize the factors that both increase and decrease plasma theophylline concentrations, as these may affect efficacy and safety. Selected herbdrug interactions university of michigan. Interaction between phenytoin and theophylline in healthy volunteers. Levofloxacin and theophylline drug interactions a study. Theophylline drug information kaiser permanente washington.
The drug is metabolised in the liver by cytochrome p450 isoenzymes, principally cyp1a2, to demethylated and hydroxylated products. To evaluate an interaction between these two drugs, we studied theophylline pharmacokinetics before, after 10 days of ticlopidine administration, and 1 month later in. Theophylline is a drug that has been used for asthma disease, for more than 80 years. Calculate initial dosage using the following equation. To reduce the risk of developing potentially dangerous drug interactions with theophylline, you should talk with your healthcare provider or pharmacist about any theophylline interactions that may apply to you. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is. Although hundreds of drug interactions have been documented, relatively few are of enough clinical significance to constitute a contraindication to simultaneous use or to require a change in dosage. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage. Adjust oxtriphylline, theophylline theophylline dose. Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things. Theophylline and its interactions1 cleveland clinic.
Theophylline s first clinical use came in 1902 as a diuretic. If patient is already taking theophylline, give smaller loading dose. Theophylline toxicity due to drug interaction sciencedirect. Montelukast has fewer drug interactions than either zafirlukast or zileuton. Aminophylline was administered intravenously, followed by a 30h blood sampling period. Individual patients may experience larger changes in serum theophylline concentrations than the value listed. Plasmatheophylline concentration is measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. During treatment with theophylline, do not start or stop taking st. Theophylline american journal of respiratory and critical. Competitive displacement interactions displaced drug displacer anti coagulants phenylbutazone, chloral hydrate increased clotting tme. Food interactions with sustainedrelease theophylline.
Theophylline is the generic name for the prescription drugs uniphyl in canada and theo24. Theophylline new perspectives for an old drug american. It took an additional 20 years until it was first reported as an asthma treatment. In the midseventies the first preparations for use with a dosage interval of 12 hours twicedaily preparations were introduced.
Drugdisease interactions of theophylline with cirrhosis, congestive heart failure, chronic obstructive. The major mechanism for distribution interaction is alteration in proteindrug binding. The plasmatheophylline concentration is increased in heart failure, hepatic impairment, and in viral infections. Blocks adenosine receptors, often necessitating a higher dose of adenosine to achieve the desired effect. When theophylline is given with enteral tube feedings, blood levels may be decreased due to interference with its absorption. Distribution interactions are those where the distribution pattern of the object drug is altered. Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e. When repaglinide was coadministered with theophylline, the only pharmacokinetic change was that the peak plasma theophylline concentration was slightly reduced.
Plasma theophylline concentrations should be checked if there are any adverse effects or if there are concerns about compliance. Theophylline has also been combined successfully with inhaled steroids. Definition drug interaction is defined as the pharmacological activity of one drug is altered by the concominant use of another drug or by the presence of some other substance. A case report and study of the influence of thiabendazole and mebendazole on theophylline pharmacokinetics in adults author links open overlay panel doreen schneider pharm. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being present in tea camellia. A case report and study of the influence of thiabendazole and mebendazole on theophylline pharmacokinetics in adults. Theophylline and alcohol drug interactions a study of fda. Its available as an oral solution, an extendedrelease tablet, and an extendedrelease capsule. Theophylline uniphyl and theo24 side effects, dosage. Th attained during therapy for asthma and improved pulmonary function or unwanted side effects, serves to link the. Its also available in an intravenous iv form, which is. Tobacco and marijuana smoke including secondhand exposure generally reduces, while caffeine increases, blood levels. Although hundreds of drug interactions have been documented, relatively few are of enough clinical significance to constitute a contraindication to simultaneous. Perhaps the most serious problem encountered in analysing such reports is the consistent absence of any effort beyond that of reading the label to establish a positive identification of the herb involved, and to exclude the effect of contaminants or adulterants.
In patients taking many drugs, however, the likelihood of significant drug interactions is increased. If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage. Theophylline, also known as 1,3dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease copd and asthma under a variety of brand names. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline effect on drug levels effect on theophylline levels potential clinical effects mechanism of interaction management. Drug interactions fall into three broad categories. Subjects were randomized to receive thiabendazole or mebendazole, then crossed over to receive the other therapy. The effect of drug interactions on costs and other outcomes for hospitalized patients receiving warfarin or theophylline was studied. T here is a strong relationship between the number of medications taken and the likelihood of a potentially serious drug drug interaction. The plasmatheophylline concentration is decreased in smokers, and by alcohol consumption.
Since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. Theo 24, theocron theophylline dosing, indications. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is updated regularly. This study is created by ehealthme based on reports of 26 people who take theophylline and alcohol from food and drug administration fda, and is updated regularly.
Theophylline and aminophylline are used systemically carried in the blood stream through the body and have side effects throughout the body. See what others have said about theophylline, including the effectiveness, ease of use and side effects. Interactions between theophylline and salbutamol on cytokine. To determine a change in theophylline pharmacokinetics during concomitant thiabendazole or mebendazole therapy, we studied six normal, healthy male volunteers. Dailymed theophylline anhydrous theophylline tablet. Theophylline interacts with a wide variety of drugs. Currently, theophylline is being used predominantly as sustainedrelease capsules or tablets. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
We would like to show you a description here but the site wont allow us. Many reports of herbinduced interactions lack crucial documentation on temporal relations and concomitant drug use. The drug was prescribed in a syrup up to the 1970s as theostat 20 and theostat 80, and by the early 1980s in a tablet form called quibron. Induction of cyp1a2 results in a more rapid clearance of theophylline, which leads to reduced, and most likely subtherapeutic, serum theophylline concentrations. Pharmacokinetic drug interaction profiles of proton pump. Theophylline and antiparasitic drug interactions chest. Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see. In addition, its low cost makes lowdose theophylline in combination with a generic inhaled corticosteroid the most cost effective way to manage persistent asthma in developing. Selected herbdrug interactions herb common use may interact with potential effect alfalfa medicago sativa multiple, including treatment of arthritis, asthma, dyspepsia, hyperlipidemia, and diabetes anticoagulants 1,2 alfalfa contains coumarin constituents and vitamin k. Adverse drug interaction involving pancuronium and aminophylline. Dailymed theophylline theophylline anhydrous solution. Therapeutic consequences of drug interactions with theophylline.
Macrolide antibiotics, including troleandomycin and erythromycin, cimetidine, and allopurinol, have the capability of decreasing theophylline clearance with resulting increased serum levels, while phenytoin increases theophylline clearance. However, the possible interaction between theophylline and. Concerning drug interactions with theophylline journal of. To minimize potential for interaction, you may interrupt the feeding for one hour before and one hour after the theophylline dose.
Effect of drug interactions on outcomes of patients. Theophylline interactions learning article pharmaceutical. The cyp2c19mediated interaction that seems to exist between clopidogrel and. The effect of phenytoin, 100 mg thrice daily for 3 weeks, on theophylline disposition was studied in eight healthy volunteers. The clinician should not assume that a drug does not interact with theophylline if it is not listed here. Since 1983, theophylline preparations that can be given with an interval of 24 hours oncedaily preparations have become available. Its used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest. Differences in the halflife of theophylline are important because. Pdf interactions between theophylline and salbutamol on. See what the interactions are and for which people.